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This technology is similar to liposomal entanglement technology (Riva et al., 2019)

Those responding positively are offered the opportunity to consent in advance to active enrolling trials

Common gastrointestinal side effects include: Nausea the most frequently reported side effect, particularly during dose escalation Vomiting often linked to nausea and typically dose-dependent Diarrhoea and constipation both have been reported, reflecting altered gut motility Decreased appetite a desired therapeutic effect, but one that requires monitoring to ensure adequate nutrition Severe or prolonged vomiting and diarrhoea can lead to dehydration and, in some cases, acute kidney injury (AKI)

(OUP Academic) What it doesnt do (important for expectations) AOD-9604 is not designed to: strongly suppress appetite, slow gastric emptying, meaningfully lower A1c by itself